Liderazgo de la mujer en la investigación clínica: estudio observacional retrospectivo durante dos décadas en España / Women's leadership in clinical research: A retrospective observational study over two decades in Spain

Antecedentes y objetivo Los datos disponibles avalan las diferencias por género en el liderazgo de las investigaciones clínicas (IC). Este estudio analiza en qué medida las mujeres lideran estas investigaciones. Materiales y métodos Estudio observacional retrospectivo en un hospital universitario terciario asociado a uno de los institutos de investigación sanitaria más importantes de España. Analizamos los investigadores principales (IP) por género (2001-2020). Variable principal: proporción de IC lideradas por mujeres durante el período de estudio. Variables secundarias: diferencias de IP por género según el tipo de estudio: ensayos clínicos (EC) o estudios de no-intervención (ENI) y según la financiación. Fuentes de datos: registros del Comité de Ética en Investigación con medicamentos (CEIm) y del Departamento de Recursos Humanos. Resultados Durante el estudio, el CEIm aprobó 8.466 protocolos; el 52% (4.408/8.466) fueron EC y el resto, ENI. Las mujeres lideraron un 39,7% (3.360/8.466) del total. La brecha de género se observó principalmente en EC: las mujeres fueron IP de un 31,5% de ellos (1.391/4.408) y de un 48,5% (1.969/4.058) de los ENI. Ello a pesar de la tendencia creciente del número de facultativas. Los estudios de financiación privada fueron más comúnmente liderados por hombres. Conclusiones Nuestros resultados demuestran que existe una infrarrepresentación de las mujeres en puestos de liderazgo en la investigación, principalmente en aquellos con financiación privada. Este estudio refuerza la idea de que todavía queda un largo camino por recorrer en este campo. Se necesitan más estudios para la identificación de diferencias existentes que permitan implantar cambios a nivel institucional y cultural que promuevan la igualdad de género en el ámbito de la investigación clínica (AU)

Background and objective Available data support differences by gender in the leadership of clinical investigations (CI). This study analyzes to what extent women lead these investigations. Materials and method Observational-retrospective study in a tertiary university hospital associated with one of the most important health research institutes in Spain. We analyzed the principal investigators (PI) by gender from 2001 to 2020. Main outcome: proportion of CI led by female doctors (FD) during the study period. Secondary outcomes: differences in PI by gender according to the type of study: clinical trials (CT) or non-interventional-researches (NIR) and according to type of funding. Data sources: Research Ethics Committee (REC) and Human Resources Department registries. Result During the study, the REC approved 8,466 protocols, 52% (4,408/8,466) were EC, the rest were NIR. Women led 39.7% (3,360/8,466) of the total. The gender gap was observed mainly in EC: FD were IP of 31.5% of them (1,391/4,408) and 48.5% (1,969/4,058) of NIR. This despite the increasing trend in the number of FD staff. By type of funding, when the studies were supported by private sector there was a wider gap markedly unfavorable for women. Conclusions Our results show that there is underrepresentation of women in research leadership, mainly those with private financing. This study reinforces the idea that there is still a long way to go in this field. More studies are necessary to identify the existing differences that allow the implementation of actions at the institutional and cultural level that promote gender equality in the field of clinical research (AU)

Women's leadership in clinical research: A retrospective observational study over two decades in Spain.

BACKGROUND AND OBJECTIVE: Available data support differences by gender in the leadership of clinical investigations (CI). This study analyzes to what extent women lead these investigations. MATERIALS AND METHODS: Observational-retrospective study in a tertiary university hospital associated with one of the most important health research institutes in Spain. We analyzed the principal investigators (PI) by gender from 2001 to 2020. MAIN OUTCOME: proportion of CI led by female doctors (FD) during the study period. SECONDARY OUTCOMES: differences in PI by gender according to the type of study: clinical trials (CT) or non-interventional-researches (NIR) and according to type of funding. DATA SOURCES: Research Ethics Committee (REC) and Human Resources Department registries. RESULTS: During the study, the REC approved 8466 protocols, 52% (4408/8466) were EC, the rest were NIR. Women led 39.7% (3360/8466) of the total. The gender gap was observed mainly in EC: FD were IP of 31.5% of them (1391/4408) and 48.5% (1969/4058) of NIR. This despite the increasing trend in the number of FD staff. By type of funding, when the studies were supported by private sector there was a wider gap markedly unfavorable for women. CONCLUSIONS: Our results show that there is underrepresentation of women in research leadership, mainly those with private financing. This study reinforces the idea that there is still a long way to go in this field. More studies are necessary to identify the existing differences that allow the implementation of actions at the institutional and cultural level that promote gender equality in the field of clinical research.

New multiproxy data obtained from the sedimentary fill of the Ría de Ferrol, NW Iberia.

Several gravity cores and vibro-cores were recovered from selected sites in the inner sector of Ría de Ferrol, NW Iberia (Muñoz Sobrino et al., 2021) [1]. These sediment cores were obtained during the surveys ECOMER-2014 and ECOMER-2015, developed from 2014 to 2015 on-board the R/V Mytilus (Consejo Superior de Investigación Científica) and the Amarradores Mil (Amarradores del Puerto y Ría de Ferrol, S.L.), respectively. Sedimentary and other multiproxy data presented here belong to four selected sediment cores located in the innermost part of the study area. Two were recovered using a gravity corer and another two using a vibro-corer. The depth of the cores and samples obtained is referred to the NMMA (the mean sea level in Alicante), which is the Spanish orthometric datum. One half of each core was subjected to non-destructive analysis using an ITRAX core scanner providing X-ray fluorescence (XRF) elemental data. Particle size distribution was characterised by laser diffraction. For radiocarbon dating, well-preserved articulated valves, small remains of wood and very organic bulk sediment from one location free of biogenic gas were selected. Palynological analyses were performed on selected sections of the sediment. All samples were spiked with Lycopodium spores for absolute palynomorph estimation and analysed using 400x and 600x magnifications. The ratio of dinoflagellate cyst concentrations to pollen, fern spore and dinoflagellate cyst concentrations (D/P ratio, ranging between 0 and 1) was calculated for each sample to show the temporal variation. Combined seismic, lithological, elemental, chronological and palynological data enable reconstructing the environmental changes that occurred during the local marine transgression. Besides, the combination of evidence identified may also be applied to other areas or periods in order to perform local reconstructions of changing coastal ecosystems. This type of high-resolution spatial-temporal reconstructions of past changes in estuarine environments may be a valuable tool for modelling, predicting and managing the changes and threats linked to the global warming and sea-level rise associated.

Linfadenopatía axilar por rotura de prótesis mamaria de silicona / No disponible

Las prótesis de silicona han sido usadas durante muchotiempo como implantes para el aumento mamario o para lareconstrucción tras cirugía oncológica. La rotura de unaprótesis es una complicación reconocida de esta cirugía. Suincidencia se desconoce, aunque sabemos que se incrementaal aumentar la edad de la prótesis.Si la silicona alcanza un ganglio linfático axilar puede provocardolor local o aumento del mismo, si bien, el procesosuele ser asintomático y verse como hallazgo incidental al realizaruna mastectomía en pacientes con antecedentes de mamoplastia.Presentamos un caso de linfadenopatía axilar por siliconatras rotura de prótesis mamaria, y realizamos una revisión delas complicaciones más habituales del uso de este material, enfatizandoen la linfadenopatía a propósito del caso(AU)

Silicone breast prostheses have been widely used for a longtime for breast augmentation or for reconstruction after cancersurgery. Rupture of prostheses is a known complication of thistype of surgery. Its incidence is unknown, even though it is knownthat there is an increase of rupture as the prostheses ages.If the silicone reaches an axilary lymph node, it can causelocal pain or enlargement in size. Even though, the processnormally does not result in these issues. It is frequently detectedas an incidental finding after performing a mastectomy aftermammaplasty.We present a clinical case of axillary lymphadenopathy associatedwith the rupture of a mammary silicone prostheses,and we review the most common and usual complicationswhen using this material, especially when dealing with a caseof lymphadenopathy(AU)

Automatic habitat classification methods based on satellite images: a practical assessment in the NW Iberia coastal mountains.

Although remote sensing is increasingly in use for habitat mapping, traditional image classification methods tend to suffer shortcomings due to non-normality of spectral signatures, as well as overlapping and heterogeneity in radiometric responses of natural and semi natural vegetation. Methods using non-parametric classifiers and object-oriented analysis have been suggested as possible solutions for overcoming these limitations. In this paper, we aimed at evaluating the performance of some of these techniques for the European Natura 2000 network of protected areas habitats mapping. For this purpose, we tested different methods of supervised image classification in the Northern Mountains of Galicia, Spain, an area included in the Natura 2000 network, which is characterized by a highly heterogeneous landscape. Methods involved the use of maximum likelihood and nearest neighbour decision rules in per-pixel and per-object classification analyses on Landsat TM imagery. Per-object classifications were completed using the segment mean and segment means plus standard deviation feature spaces. The results showed the existence of significant differences in the accuracies for the different methodologies, their strengths and weaknesses and identified the most adequate approach for habitat mapping. Analyses pointed out that significant improvements in accuracy were achieved only under certain combinations of per-object analysis, non-parametric classifiers and high dimensionality feature space.

Acute toxicity of LAS homologues in marine microalgae: esterase activity and inhibition growth as endpoints of toxicity.

The toxicity of two linear alkylbenzene sulfonate (LAS) homologues (C(10) and C(13)) was evaluated in four marine microalgae (Nannochloropsis gaditana, Tetraselmis suecica, Rhodomonas salina, and Isocrysis galbana), using growth inhibition rate and esterase activity (measured by flow cytometry) as endpoints. The inhibitor effect was higher for the C(13) LAS homologue than for C(11), in both responses analyzed. When both endpoints were compared, the growth inhibition rate was between 2 and 5 times more sensitive than esterase activity. Among microalgae species, R. salina exhibited the highest sensitivity.